The COVID-19 pandemic has created many stressors and challenges across all levels of low to highly resourced health systems. However, it has also shown the incredible number of opportunities for innovation, ingenuity and system re-engineering. We think it is time to support a paradigm change and advocate for healthcare’s next big investment: intentional and embedded partnerships between clinicians, designers, and architects with dedicated resources to ensure an effective collaborative environment to help solve healthcare’s greatest challenges.